Members of the Paust laboratory are interested in the development and testing of novel immunotherapies that elicit clinically relevant Natural Killer cell-mediated anti-pathogen or anti-tumor immunity.
Members of the Paust laboratory are interested in the development and testing of novel immunotherapies that elicit clinically relevant Natural Killer cell-mediated anti-pathogen or anti-tumor immunity. Our research program is centered on the discovery that subsets of NK cells are long-lived and capable of antigen-specific immunological memory to viruses and altered self, giving precedence to investigations that seek to exploit NK cell activity to prevent or cure disease. Currently, we are pursuing three specific scientific goals: 1) Identification of the mechanisms by which subsets of murine and human NK cells mediate antigen-specific immunological memory responses; 2) Identification of NK cell-specific immune correlates of protection from infection or malignancy; 3) Development of effective, host-protective vaccine or therapeutic approaches that elicit potent NK cell-mediated recall responses in vivo. To enable our studies, we routinely utilize mouse models, xenograft models, and clinical samples for the immunological analyses of innate and adaptive NK cell-mediated immune responses.
Silke Paust is investigating the roles lung Natural Killer cells play in clearing influenza virus infection and preventing...
New and existing customers at The Jackson Laboratory can enroll to save 10% on many popular JAX® Mice strains.
Paige Ramkissoon reflects on how her time in the JAX Postbac program has prepared her for the next step in her academic...
Employs genomics approaches to investigate the impact of aging on brain cancer progression.
With $13 million in renewed support, Karolina Palucka will further study how aging affects airway epithelial cells’...
Reenergizing exhausted T cells, with help from a rare immune cell known as a basophil, can kickstart the immune system into...
Earlier this year, The Jackson Laboratory’s NCI-designated Basic Research Cancer Center and the American Cancer Society (ACS) teamed up to...
Understanding the molecular mechanisms underlying monogenic retina diseases
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study connections between...
I am fascinated by the biology of the immune system, particularly innate cells, in physiological or pathological contexts. The...
The overall focus of my research is on the anticancer activity and immune surveillance of Natural Killer cells in cancer, as well as their...
Members of the Paust laboratory are interested in the development and testing of novel immunotherapies that elicit clinically relevant...
My primary research focuses on how encounters with antigens, whether through vaccination or infection, significantly influence the...
I am interested in what molecular mechanisms control regeneration, particularly focused on how changes in immune cells and signaling...
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