Antibody Therapeutics

Antibody Drug Discovery

Introducing our Partnership with AbTherx

JAX has partnered with AbTherx to offer new transgenic platforms for monoclonal, bispecific, and multispecific antibody discovery. We've combined our decades of experience in transgenic mice with AbTherx's deep knowledge in antibody discovery to help you create the next generation of antibody therapeutics. We offer specialized models designed to generate antibodies with the desired diversity, developability, and affinity required to accelerate your antibody discovery programs and bring life-saving therapeutics into the clinic faster.

Atlas^™ Full Human Diversity Mouse for Monoclonal Antibody Discovery

Thoughtfully designed to overcome many of the challenges with legacy technologies.

• Engineered knock-in of full diversity, human variable heavy and kappa light chains into endogenous mouse loci
• Selected variable regions comprise >99% of commonly expressed human sequences
• Incorporates only functional heavy and kappa light chain domains to promote optimal B-cell rearrangement

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Atlas^™ Binary Fixed Light Chain Mouse for Bispecific and Multispecific Antibody Discovery

Designed to enable the creation of bispecific and multispecific therapies that mimic native antibody structures.

• Generates antibodies allowing pairing of heavy and light chains without linkers, fusions, or modifications
• Supports target-driven selection from one of two fixed light chains in the context of a full diversity heavy chain
• Allows for improved diversity and hit recovery through optionality of two fixed kappa light chain pairings

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