Preclinical Neurobiology Platforms

We share your commitment to finding solutions for neurodegenerative, neuromuscular, and neurodevelopmental diseases. Our dedicated team of preclinical neurobiology experts has unparalleled experience with unique mouse models for neurological disease.
With leading-edge science, a wide range of neuroscience mice, and a collaborative approach, we provide the resources and expertise you need to advance novel therapies and make a meaningful impact in human health. Let us simplify your neurobiological research process and accelerate your path to breakthroughs.

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Preclinical Neurobiology Platforms at The Jackson Laboratory

Routes of Compound Administration

JAX technicians are extensively trained and rigorously tested to ensure safe and consistent technique is used for all procedures. Our training program ensures that your study timelines and outcomes are not delayed or impacted by changes in personnel or lack of expertise on specific assays. For JAX Preclinical Services, we offer dosing of your test article or control treatment(s) through a wide variety of common and technically challenging routes of administration, across the lifespan of your mouse model.

Technique Adult Neonatal
Intracerebroventricular (ICV) Yes Yes
Oral (DO,PO) Yes Yes
Intraperitoneal (IP) Yes Yes
Subcutaneous (SC) Yes Yes
Retro-Orbital (RO) Yes Yes
Intravenous (IV) Yes Yes
Intramuscular (IM) Yes —
Intradermal (ID) Yes —
Superficial Temporal Vein — Yes
Cisterna Magna Yes Yes
Intrathecal (IT) Yes Yes
Intratracheal Yes —

Let's Talk iPSCs and Their Value in Tackling Neurodegenerative Diseases

Induced pluripotent stem cells (iPSCs) have become an invaluable tool for modeling neurodegenerative disorders and are increasingly used in drug discovery, safety pharmacology and toxicology, and clinical applications to treat human disease. In this session, Dr. Mark Cookson, senior investigator at the NIH National Institute on Aging, talks about the unique aspects of this collection and how it can benefit the wider scientific community in their shared quest to understand and fight ADRD.

Watch the Video about iPS Cells

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JAX Tech Talk Video - iPSCs and Their Value in Tackling Neurodegenerative Diseases

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Research Model Platforms

JAX Center for Rare Disease

Model-AD

Immune Humanized Mice
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