The Joy Lab is interested in understanding how circuits in the brain rewire after a stroke and other CNS injuries, with the goal of identifying molecular and circuit principles for recovery.
Stroke causes death of brain tissue leading to long-term motor and cognitive deficits, making it the leading cause of serious-long term disability. With the loss of brain regions after a stroke, surviving circuits rewire and attempt to adapt to this loss. There is little understanding on fundamental mechanisms of how circuits rewire and the consequence of these rewiring processes on brain function. The focus of the Joy lab is to understand mechanisms of circuit reorganization, identify maladaptive and adaptive processes and determine how these processes change the way the brain encodes motor and cognitive functions. Our investigations span synaptic, molecular, circuit and behavioral domains to identify circuit mechanisms and molecular signatures that drive recovery and identify therapeutic targets for stroke. We are also interested in translating these findings to other disease models of CNS injuries. We use a host of techniques including but not limited to large-scale mesoscopic calcium imaging, widefield imaging, optogenetics, transcriptomics, gene/protein targeting with viral vectors or drugs and ethological measurements of behavior.
I study neural circuit remapping post-stroke using advanced techniques to understand its mechanisms and develop effective...
Provides administrative support to research faculty and their lab personnel.
Working with cellular neuron models to understand mechanisms of resiliency and aging.
Employs genomics approaches to investigate the impact of aging on brain cancer progression.
The Paigen Fellowship supports postdoctoral associate Abdulfatai Tijjani's humanistic approach to research.
I am passionate about the research intersection of generative AI, biomedical imaging, computational neuroscience, and big...
JAX’s 'Scientifically Speaking' virtual series continues May 7, featuring two postdoctoral associates taking on the challenge of...
Elevate your research capabilities and contribute to shaping the future of neurological health.
This webinar explores key considerations in study design with neurological models, including best practices for model selection, study...
At The Jackson Laboratory, we're committed to promoting research by making the most commonly used strains more accessible to you....
New and existing customers at The Jackson Laboratory can enroll to save 10% on many popular JAX® Mice strains.
In the dyW strain (B6.129S1(Cg)-Lama2tm1Eeng/J, 013786), knock-out of the laminin alpha 2 gene models merosin-deficient congenital muscular...
C57BL/10ScSn-Dmdmdx/J mice (001801), commonly called mdx, are the most published model of Duchenne’s muscular dystrophy. The mice carry a...
D2.B10-Dmdmdx/J (013141) is a newer JAX strain created by backcrossing 001801 mice onto the DBA/2J background. This new strain better...
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