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Blog PostFebruary 14, 2022Systemic Immune Responses - Humanized Mice
The Jackson Laboratory (JAX) has developed a versatile toolset of mouse models capable of supporting extensive functional components of the human immune system. These mice provide a preclinical research platform that yields sensitive, reproducible results to screen drug candidates for inflammatory responses. -
Blog PostDecember 09, 2021Studying CRS in a Diverse Population
To understand the future of these preclinical studies, we sat down with James Keck, Ph.D., who was recently recognized as a JAX President’s Innovation Fellow for his work creating mouse-based platforms to study the immune system, and evaluate new therapeutics for both safety and efficacy. -
Research HighlightOctober 20, 2020Exploring autoimmune neuritis associated with type 1 diabetes
New JAX research brings significant elements of immunology and neurodegeneration research into play. -
Blog PostJuly 08, 2019Using JAX lupus phenotype models to assess CAR-T therapy
The development of novel treatments for systemic lupus erythematosus (SLE) has been a slow process, a new therapy approved in 2011 was the first in over 50 years. The increasing understanding of SLE pathogenesis combined with burgeoning new immunomodulatory therapies, such as CAR-T, may enable the development of more SLE-specific treatments.
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Research HighlightDecember 13, 2021Examining the immune response to cancer on a genetic level
The V Foundation for Cancer Research has awarded a grant to JAX's Lucas Chang for genetic studies of the immune response to cancer. -
Press ReleaseApril 13, 2021Lenny Shultz joins new JDRF Center of Excellence to advance Type 1 Diabetes research
JDRF has announced the launch of the JDRF Center of Excellence in New England. The new center is comprised of a team of experts from institutions in New England including JAX’s Lenny Shultz, Ph.D. -
Research HighlightMay 15, 2020A needle in a haystack: Finding how a genetic variant increases the risk of autoimmune diseases
More than 98% of the genome doesn’t code for proteins, but recent findings show that many non-coding sequences play important roles in health and disease. -
Research HighlightSeptember 26, 2018Making B-lymphocyte targeting work in treating type 1 diabetes
$2.2M grant to JAX Professor David Serreze will fund search for new approaches to fighting autoimmune destruction
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