Many common inherited human diseases — such as diabetes, cardiovascular disease, obesity, autoimmune disease and cancer — are genetically complex, resulting from the interaction of more than one gene. Advances in genetic methods and the completed sequencing of the human and mouse genomes make it feasible to detect, genetically map and identify the genes underlying these complex disorders.
The SMSR is a resource of special strains of mice that are important tools for genetic analysis of such complex diseases. They include panels of recombinant inbred (RI) and chromosome substitution (CS) strains, also known as consomic strains.
The SMSR imports, cryopreserves and distributes RI and CS strain panels that are vital to discovery of quantitative trait loci (QTL) and ultimately genes responsible for complex diseases. QTL and genes identified by QTL analysis in mouse models often correlate with homologous regions in the human genome. Thus, connecting phenotype and genotype in mice may translate into identification of genes responsible for human complex diseases such as atherosclerosis, diabetes, obesity, asthma, autoimmunity and hypertension.
Recombinant inbred and chromosome substitution strain panels
Panel Name* |
Type |
Progenitor strains |
|
RI |
A/J |
C57BL/6J |
|
RI |
C57BL/6J |
A/J |
|
RI |
C57BL/6J |
DBA/2J |
|
RI |
C57BL/6J |
C3H/HeJ |
|
RI |
BALB/cBy |
C57BL/6By |
|
RI |
ILS/IbgTejJ |
ISS/IbgTejJ |
|
C57BL/6J-Chr#A/J/NaJ |
CS |
C57BL/6J |
A/J |
C57BL/6J-Chr#PWD/Ph/ForeJ |
CS |
C57BL/6J |
PWD/Ph |
Czechanski A, Byers C, Greenstein I, Schrode N, Donahue LR, Hadjantonakis A-K and Reinholdt LG. 2014. Derivation and characterization of mouse embryonic stem cells (mESCs) from permissive and non-permissive strains. Nat Protoc 9(3):559-74. PMCID: PMC4112089
Donahue LR, Hrabe de Angelis M, Hagn M, Franklin C, Lloyd KCK, Magnuson T, McKerlie C, Nakagata N, Obata Y, Read S, Wurst W, Horlein A, Davisson MT. 2012. Centralized Mouse Repositories, Mammalian Genome 23(9-10):559-71. PMCID: PMC3709583.
In addition to making these highly valuable RI and CS strains available to the scientific community, we are enhancing the value of these models through additional characterization and curation. Examples are behavioral, reproductive, immunological, blood chemistries including lipids and electrolytes, and hematological studies in the C57BL/6J-Chr#A/NaJ and C57BL/6J-Chr#PWD/ForeJ consomic panels. These data are available from the Mouse Phenome Database (MPD) website.
SNP variation data for RI strains and gene expression data for the ILSXISS RI set are also available at Mouse Phenome Database. MPD is a community resource whereby data are contributed by many different users and curated by the MPD staff at The Jackson Laboratory.
The Special Mouse Strains Resource (SMSR) is supported by the National Institutes of Health, Office of Research Infrastructure Programs/Office of the Director (grant number OD011102). Please reference this grant in citations acknowledging use of the resource.
We use cookies to personalize our website and to analyze web traffic to improve the user experience. You may decline these cookies although certain areas of the site may not function without them. Please refer to our privacy policy for more information.