Laura Reinholdt, Ph.D.
Associate Professor
Dr. Reinholdt’s research focuses on comparative and functional mammalian genomics, reproductive development and stem cell biology.
Dr. Reinholdt’s research interests are in the development and application of genetic approaches for understanding the etiology and functional consequences of genome variation in the germ line and in pluripotent cells. Dr. Reinholdt is also committed to genetic resource development and has made significant contributions to the early development of high throughput sequencing approaches for genomic discovery in the mouse genome, and more recently the development of novel ES and iPSC cell lines from genetically diverse mice that are enabling platforms for cellular systems genetics.
Education and experience
Dr. Reinholdt received her Ph.D. in Genetics from the University of Connecticut, Department of Molecular and Cellular Biology in 2001 and this was followed by a post-doctoral fellowship in Drs. John Schimenti and Mary Ann Handel’s laboratories. Dr. Reinholdt joined the Genetic Resource Science group at The Jackson Laboratory in 2008 as a Research Scientist and was promoted to Senior Research Scientist in 2015. As a principal investigator in the Mutant Mouse Resource and Research Center, as well as the Special Mouse Strains Resource and the Mouse Mutant Resource she is an expert in mouse model development, mammalian genetics and technology development. She also serves as a domain expert in Reproductive phenotyping for the Knockout Mouse Project (KOMP2) at JAX.
In addition to the development and implementation of high throughput sequencing based approaches for spontaneous mutation, transgene insertion site and translocation breakpoint discovery, Dr. Reinholdt’s laboratory developed a novel protocol for derivation of embryonic stem cell line from a variety of strains that were previously deemed recalcitrant after years of failed attempts by the scientific community. This approach is now being used to derive embryonic stem cells from a variety of strains including disease models from which in vitro tools are in demand, including mouse models of Alzheimer’s disease, cytogenetic disorders (Turner’s syndrome and Down syndrome), and tool strains for systems genetics.
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Press ReleaseOctober 25, 2023International Mammalian Genome Society recognizes JAX Scientists
Scientists from JAX are being recognized for their outstanding achievements by the IMGS, a group that fosters research in mammalian genetics, and represents its members in their professional activities. -
Research HighlightMay 09, 2023Variability in the earliest stages of development
The processes enabling pluripotency at the very beginning of life are more different between mouse strains than you might expect. -
Press ReleaseMarch 10, 2020Serving the needs of the biomedical research community
JAX receives $6.1M, 5-year NIH grant for laboratory mouse resource program. -
Press ReleaseSeptember 18, 2015
JAX, EWHA Womans University to host joint international symposium on genomic medicine Oct. 2
Six senior officials and scientists from The Jackson Laboratory (JAX) will visit Ewha Womans University in Seoul for an International Joint Symposium on Genomic Medicine on Oct. 2.
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Press ReleaseJuly 25, 2023Announcing the 2023 College Scholarship recipients
JAX is proud to announce the 2023 college scholarship recipients. The annual scholarship, now in its sixth year, recognizes high school students from underserved backgrounds pursuing careers in life sciences and health care. -
Research HighlightOctober 20, 2020From one cell to trillions: Exploring early development
JAX researchers are probing the mysteries of pluripotent stem cells; the earliest stages of life. -
Press ReleaseMay 18, 2016$3.4 million federal grant to JAX will facilitate Mendelian genetic disorder research
A research grant from the National Institutes of Health totaling $3,436,466 over four years will enable a Jackson Laboratory research group led by Senior Research Scientist Laura Reinholdt, Ph.D., to develop new data resources and mouse models to better understand Mendelian genetic disorders. -
Blog PostSeptember 09, 2015Structural variants and the limits of genome sequences
Genome sequences tell us a lot, but structural variations are also key players in health and disease.