The Unutmaz Lab
The Unutmaz Lab investigates the biology of the human immune system.
Principal Investigator
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Our research focus
Our research primarily focuses on decoding the differentiation, activation and regulation of human T cells for optimal immune responses to infectious diseases and their perturbations during chronic diseases or aging. We have contributed to the understanding of how T cell subsets are disrupted during human diseases, especially during HIV infection. Our lab has made several seminal discoveries about the diversity and mechanisms of immune suppression mediated by regulatory T cells and effector functions of human Th17 cell subsets.
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Media ReleaseOctober 29, 2024JAX researchers unveil method to map immune cell connections, predicting patient survival in cancer
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study connections between immune cells in breast cancer and melanoma -
ArticleJuly 29, 2024MODEL-AD drives progress for Alzheimer’s research
The July issue of Alzheimer’s & Dementia spotlights progress by MODEL-AD and its work to create better models for Alzheimer’s disease research and catalyze progress in the field. -
ArticleJuly 24, 2024Researchers are closing in on a mouse model for late-onset Alzheimer’s research
Mice don’t get Alzheimer’s—and while that’s good news for mice, it’s a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that’s genetically susceptible to late-onset Alzheimer’s, with potentially transformative implications for dementia research. -
Blog PostJune 04, 2024The inner space of cancer
New methods allow researchers to figure out what happens where in tumors, with important implications for improving cancer therapies.
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ArticleOctober 08, 2024Cancer research trainees advance their skills at JAX with support from the American Cancer Society
Earlier this year, The Jackson Laboratory’s NCI-designated Basic Research Cancer Center and the American Cancer Society (ACS) teamed up to have ACS-funded trainees attend advanced cancer courses at JAX, aiming to deepen their understanding of cutting-edge cancer research techniques through experiential learning. -
Media ReleaseJuly 24, 2024New analysis - targeted Alzheimer’s research and drug discovery
Researchers at The Jackson Laboratory offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer’s Disease in advance of the Alzheimer's Association International Conference, July 28 -
Research HighlightJune 05, 2024Revealing potential therapy targets for cancer
Reenergizing exhausted T cells, with help from a rare immune cell known as a basophil, can kickstart the immune system into fighting cancer. -
Featured ArticleMay 08, 2024Paige Ramkissoon reflects on postbac at JAX
Paige Ramkissoon reflects on how her time in the JAX Postbac program has prepared her for the next step in her academic training.