The Ren Lab
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
Principal Investigator
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OUR RESEARCH FOCUS
The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.
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Media ReleaseOctober 29, 2024JAX researchers unveil method to map immune cell connections, predicting patient survival in cancer
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study connections between immune cells in breast cancer and melanoma -
ArticleJuly 29, 2024MODEL-AD drives progress for Alzheimer’s research
The July issue of Alzheimer’s & Dementia spotlights progress by MODEL-AD and its work to create better models for Alzheimer’s disease research and catalyze progress in the field. -
ArticleJuly 24, 2024Researchers are closing in on a mouse model for late-onset Alzheimer’s research
Mice don’t get Alzheimer’s—and while that’s good news for mice, it’s a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that’s genetically susceptible to late-onset Alzheimer’s, with potentially transformative implications for dementia research. -
Blog PostJune 04, 2024The inner space of cancer
New methods allow researchers to figure out what happens where in tumors, with important implications for improving cancer therapies.
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ArticleOctober 08, 2024Cancer research trainees advance their skills at JAX with support from the American Cancer Society
Earlier this year, The Jackson Laboratory’s NCI-designated Basic Research Cancer Center and the American Cancer Society (ACS) teamed up to have ACS-funded trainees attend advanced cancer courses at JAX, aiming to deepen their understanding of cutting-edge cancer research techniques through experiential learning. -
Media ReleaseJuly 24, 2024New analysis - targeted Alzheimer’s research and drug discovery
Researchers at The Jackson Laboratory offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer’s Disease in advance of the Alzheimer's Association International Conference, July 28 -
Research HighlightJune 05, 2024Revealing potential therapy targets for cancer
Reenergizing exhausted T cells, with help from a rare immune cell known as a basophil, can kickstart the immune system into fighting cancer. -
Featured ArticleMay 08, 2024Paige Ramkissoon reflects on postbac at JAX
Paige Ramkissoon reflects on how her time in the JAX Postbac program has prepared her for the next step in her academic training.