Utilizes high-resolution genome-wide open chromatin maps to study the mechanistic basis for differences in healthy immune responses of young and elder patients.
My research seeks to understand genomic and epigenomic causes of phenotypic variation,and it is motivated and informed by the exuberant intricacy of cause-effect associations that link inheritable and non-inheritable genetic factors to the manifestation of complex phenotypes. In my work, I routinely use and develop computational and statistical approaches to interrogate genomic and epigenomic data for patterns that help elucidate the causal processes behind healthy and pathological variants at sub- and supra-cellular levels of phenotypic organization. Presently, we are using high-resolution, genome-wide open chromatin maps to study the mechanistic basis for differences in healthy immune responses of young and elder patients, with a focus on age-driven euchromatin and transcription factor accessibility dynamics. Outcomes from these efforts will provide us with valuable insights regarding the re-wiring dynamics of regulatory networks of the aging immune system, which will contribute to our understanding of the mechanistic underpinnings of age-related diseases, as well as a basis to elucidate the causes of variation in individual patient responses to their treatment and prevention.
Building, understanding and applying a dictionary of genetic effects, National Institutes of Health R01 GM094424. 2010-2014. $1,594,731. PIs: Dr. David Houle, Dr. Ian Dworkin.
The dictionary of genetic effects and the language of morphology, National Science Foundation DEB-0950002. 2010-2014. $ $688,197. PIs: Dr. David Houle, Dr. Eladio Márquez.
Phylogenetic persistence of modularity of the rodent skull, National Science Foundation DDIG 0407570. 2004. $11,995. PIs: Dr. Miriam Zelditch, Eladio Márquez. • Hinsdale Fellowship, University of Michigan Museum of Zoology. 2004. $1,870.
Assessing developmental constraints: isolating the developmental and adaptive components of covariance patterns, Society for Integrative and Comparative Biology, Fellowship of Graduate Student Travel. 2003. $2,000.
Fellowship to support Undergraduate thesis. Department of Professional Studies, Universidad Simon Bolivar, Venezuela. 1996. Bs. 100,000 (approx. $340 at 1996 exchange rate).
Fellowship to support Ph.D. studies at University of Michigan granted by the Direction for Professorial Development, Universidad Simon Bolivar, Caracas, Venezuela (2000-2002).
Educational Credit for Ph.D. studies from Gran Mariscal de Ayacucho Foundation, Caracas, Venezuela (2000).
Honorable mention for undergraduate thesis, Universidad Simon Bolivar, Caracas, Venezuela (1997).
Scholarship for undergraduate studies from Gran Mariscal de Ayacucho Foundation, Caracas, Venezuela (1993).
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