Jennifer Trowbridge, Ph.D.
Professor, The Dattels Family Chair
Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.
The Trowbridge laboratory studies cell fate regulation within the hematopoietic system. Our current focus is on the epigenetic regulation of hematopoietic stem cell (HSC) and progenitor cell lineage commitment in three contexts: (1) normal blood development and maintenance, (2) alterations that occur during the process of aging, and (3) alterations that occur during the process of transformation giving rise to leukemia. Our ultimate goal is to reveal epigenetic patterns and processes that are uniquely deregulated during aging and/or transformation, which can be used to identify novel biomarkers of disease and targets for development of therapeutics.
Podcasts featuring Professor Trowbridge:
"Review Series on Hematopoietic Stem Cells" | Blood Podcast
"Regulation of Stem Cells in the Blood featuring Dr. Jennifer Trowbridge" | The Stem Cell Podcast
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Blog PostJune 20, 2024How old is your bone marrow?
Researchers at JAX reveal that hematopoietic stem cells age differently in genetically identical mice, offering new pathways for interventions to preserve health with aging. -
Research HighlightFebruary 22, 2023Examining hematopoietic stem cells decline with age
In a new paper, Jennifer Trowbridge presents the factors and processes that contribute to Hematopoietic stem cells decline with age. -
Research HighlightSeptember 28, 2022Tipping the scale toward favorable outcomes in cancer and beyond
Jennifer Trowbridge and her team reveal the molecular signaling pathway most associated with clonal hematopoiesis and how blocking a specific cell-surface receptor in the pathway can tip the balance toward positive health outcomes. -
Press ReleaseMay 03, 2022JAX announces 2022 recipients of the JAX Scholar awards
The Jackson Laboratory is proud to announce the 2022 recipients of the JAX Postdoctoral Scholar award. Eric Bogenschutz, Jayna Mistry, and Kwondo Kim represent forward-thinking research, proven leadership, and engagement with the scientific community.
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Research HighlightJuly 11, 2023New research ties clonal hematopoiesis to protection against Alzheimer’s disease
In a Nature Medicine publication, Jennifer Trowbridge and collaborators discuss the need to further define the relationship between clonal hematopoiesis and age-related diseases. -
Press ReleaseJanuary 24, 2023Jennifer Trowbridge receives award from The Mark Foundation for Cancer Research
Trowbridge has been recognized as an outstanding early-career scientist and will receive a $750,000 award. -
Featured ArticleSeptember 13, 2022The Dattels Family Chair - Powering Leukemia Research at JAX
Associate professor Jennifer Trowbridge, Ph.D., whose laboratory at JAX’s Bar Harbor campus focuses on the study of cellular changes that can lead to leukemia, has been appointed as the inaugural Dattels Family Chair. -
Research HighlightDecember 13, 2021Examining the immune response to cancer on a genetic level
The V Foundation for Cancer Research has awarded a grant to JAX's Lucas Chang for genetic studies of the immune response to cancer.