Advanced Precision Medicine Laboratory - Research Services
APML Research Services
The JAX APML uses cutting edge technology to provide services with high quality data outputs for researchers across the globe. If there is a service you would like that you do not see on our menu please reach out to us via the inquiry button below or by email to cgl_cs@jax.org.
Research Services Highlights:
- Works with scientists and researchers internationally to meet project needs.
- Uses high end cutting edge technology such as the Illumina NovaSeq 6000.
- Offers competitive tiered pricing for all of our assays.
- Data will be delivered quickly to allow researchers to keep momentum.
- Available for custom project requests.
Next Generation Sequencing Services
The JAX APML group offers a range of next generation sequencing services to support researchers and their mission. We provide high quality data within a reasonable time frame that allows researchers to boost scientific investigations.
| Service | Capability | Price | Price Details |
| Whole Exome Sequencing | Using 100-200ng of Genomic DNA from FFPE, fresh-frozen tissue, blood, or saliva, probe enrichment will target exons via hybrid capture spanning up to 35.1 Mb of the Human Genome. Median exon coverage of at least 100x. Fast turnaround times with FASTQ deliverable and tertiary analysis upon request. |
$1,550/Sample Batch minimum is 14 samples. |
Price includes cost of Blood extraction, samples will be run at 50X coverage. Tertiary analysis available upon request for additional cost. |
|---|---|---|---|
| Whole Genome Sequencing | Using 100ng of total DNA from FFPE, fresh-frozen tissue, blood, or saliva, large and small variants across the whole genome can be captured. Fast turnaround times with FASTQ deliverable and tertiary analysis upon request. |
Please Inquire |
Please note a project consultation is required for WGS projects. |
| RNASeq | Enriched FFPE and fresh-frozen tissue used to generate 76bp paired-end sequences. Fast turnaround time and FASTQ deliverable. |
$1,200/Sample Batch minimum is 8 samples. |
Price includes cost of FFPE extraction, for samples run at 40 million reads. Tertiary analysis available upon request for additional cost. |
| JAX SomaSeq RUO | Using FFPE blocks or slides, the test reports on 517 cancer related genes for assessment of all DNA and RNA variants such as CNVs, copy number variants, indels, and fusions using NGS. Fast turn around time with FASTQ deliverable and tertiary analysis available upon request. |
$2,700/Sample Batch minimum is 8 samples. |
Price includes cost of FFPE extraction. Tertiary analysis available upon request for additional cost. |
Array Based Technology Services
The JAX APML offers two types of array services. We use cutting edge technologies and equipment to provide high quality data to all of our customers. Tertiary analysis is available upon request for these services and we are happy to work with researchers and their teams to ensure all needs are met. If there is an array service of interest that is not listed below, please inquire with us by reaching out to cgl_cs@jax.org. The Jackson Laboratory works diligently to ensure customer needs are met and we are happy to discuss project proposals.
| Service | Capability | Price | Price Details |
| Infinium Global Diversity Array | Using DNA from cells or fresh frozen tissue, samples will be bisulfite converted, hybridized, affixed to a beadchip and stained. The 8-sample BeadChip features exceptional coverage of clinical research variants associated with disease and pharmacogenetics. The GDA is built on high density SNP global backbone optimized for cross-population imputation coverage of the genome. |
$375/Sample Batch minimum is 8 samples. |
Price includes cost of extraction. Tertiary analysis is available upon request for additional cost. |
|---|---|---|---|
| JAX OncoMethyl Array RUO | Using FFPE blocks or slides, extracted DNA will undergo bisulfite conversion. Converted DNA undergoes whole genome amplification and is processed using the Infinium MethylationEPIC Array. The machine learning algorithm used allows for classification of CNS tumors. |
$850/Sample Batch minimum is 8 samples. |
Price includes cost of FFPE extraction. Tertiary analysis is available upon request for additional cost. |
Molecular Biology Services
APML offers a variety of molecular biology techniques. Each service has a plethora of capabilities that can aid in advancing research. Tertiary analysis for ddPCR, STR, and qPCR is available upon request.
| Service | Capability | Price | Price Details |
| MGMT Promoter Methylation Array RUO | Using FFPE blocks or slides, extracted DNA will undergo bisulfite conversion. Converted DNA is amplified via qPCR. |
$300/Sample Batch minimum is 10 samples. |
Price includes cost of extraction. Tertiary analysis is avilable upon request for additional cost. |
|---|---|---|---|
| ddPCR | Droplet Digital PCR provides benefits of absolute quantification and enhanced sensitivity. Using a variety of sample inputs ddPCR can be used for TERT Promoter mutational analysis, gene expression, microRNA Analysis, CNV detection, Genome Edit detection, single cell analysis and pathogen detection. |
$100/sample |
Price per sample does not include analysis or primers/probes for project. Tertiary analysis available upon request for additional cost. |
| STR | Using as little as 2ng of DNA from extracted FFPE or .5ng from Fresh frozen tissues sequencing is performed on the ABI 3500 instrument post PCR amplification. |
$700/Sample Batch minimum is 5 samples. |
Price includes cost of FFPE extraction. Tertiary analysis is available upon request for additional cost. |
| Histology Services | Available services include: Slide Sectioning (10 unstained +1 H&E), Single Scroll, Single Slide Section 5um, and H&E staining |
Please Inquire |
Pricing will range based on specific service. |
| qPCR | qPCR is can be used for detecting, characterizing, and quanitifying nucleic acids for a variety of applications in genomics, diagnostics, drug development and more. qPCR services can accelerate research. As the widely accepted gold standard for DNA and RNA quanitifcation qpCR is sensitive and reproducible. |
$100/sample |
Price per sample does not include analysis or primers/probes for project. Tertiary analysis available upon request for additional cost. |