| MODEL |
JAX # |
TYPE |
DESCRIPTION |
REFERENCE |
SOURCE |
| Trem2 KO |
27197 |
Knock-out |
Deletion of 175bp introduces a stop codon at amino acid 17. |
|
MODEL-AD |
| Trem2*R47H |
27918 |
Knock-in |
Knock-in of R47H risk variant into mouse locus |
PMID:37016304 |
MODEL-AD |
| Trem2*R47HHSS |
33781 |
Knock-in |
Knock-in of R47H risk variant into mouse locus with humanized splice acceptor site |
|
MODEL-AD |
| Trem2*R47HNSS |
34036 |
Knock-in |
Knock-in of R47H risk variant into mouse locus with normalized splice acceptor site |
PMID:36803190 |
MODEL-AD |
| Trem2*Y38C |
29725 |
Knock-in |
Knock-in of Y38C risk variant into mouse locus |
PMID:33115519 |
MODEL-AD |
| hTREM2-KI |
38103 |
Knock-in |
Knock-in of human coding sequence replacing corresponding mouse sequence |
|
MODEL-AD |
| hTREM2-R47H_KI |
37497 |
Knock-in |
Knock-in of human coding sequence with R47H risk variant replacing corresponding mouse sequence |
|
MODEL-AD |