Late-onset AD base models
| MODEL | JAX # | TYPE | DESCRIPTION | REFERENCE | SOURCE |
|---|---|---|---|---|---|
| LOAD1 = APOE4/Trem2*R47H | 28709 | Compound knock-in | APOE4 & Trem2R47H KI | PMID:34707490 | MODEL-AD |
| LOAD2 = Aβ/APOE4/Trem2*R47H | 30670 | Compound knock-in | Humanized Aβ1-42, APOE4 & Trem2R47H KI | MODEL-AD | |
| LOAD3 = Aβ/APOE4/MAPT(H1.0) | 37778 | Compound knock-in | Humanized Aβ1-42, APOE4 & humanized TAU of H1 haplotype | MODEL-AD | |
| Aβ/MAPT(H1.0) | 38908 | Compound knock-in | Humanized Aβ1-42 & humanized TAU of H1 haplotype | MODEL-AD |