The Wang Lab
The Wang Laboratory at The Jackson Laboratory for Genomic Medicine is interested in understanding gene regulatory mechanisms that regulate leukemia survival, differentiation and therapy response.
Overcoming Drug Resistance in Hematologic Malignancies
Drug resistance continues to be the main limiting factor to achieving cures in cancer patients. The Wang laboratory is interested in investigating both genetic and non-genetic mechanisms of therapy resistance in hematologic malignancies. Here we apply a broad range of genetic tools including CRISPR-Cas9 genetic screens to identify drug-gene interactions and multi-modal single-cell technologies to reveal cell intrinsic and extrinsic (i.e., immune microenvironment) mechanisms of resistance. Overall, these studies will provide a blueprint for clinically relevant biomarkers and developing new therapeutic strategies to overcome drug resistance in cancer.
Uncovering Genetic Dependencies in Myeloid Neoplasms
Acute myeloid leukemia (AML) is an aggressive hematological malignancy that accounts for 80% of acute leukemia cases in adults. Despite recent therapeutic advances, AML is still marked by a dismal prognosis. Our laboratory is interested in identifying new therapeutic targets for AML. Here we develop and apply CRISPR platforms to understand gene regulatory networks that govern leukemia survival and differentiation. Moreover, we are interested in applying CRISPR screening approaches to identify novel synthetic lethal interactions to tumor suppressor mutations found in hematologic malignancies.
Role of RNA binding Proteins in Leukemia
Considering the importance of RNA splicing in gene regulation, cancer cells can exploit alternative splicing through various mechanisms (i.e., RNA splicing, polyadenylation) to promote tumor growth. Our laboratory has previously identified several RNA-binding proteins (RBPs) that are critical for leukemia growth, differentiation, and modulate drug response. Therefore, a primary focus of the laboratory is to advance our understanding of RNA biology in cancer biology. Here we will use state-of-the-art technologies to functionally interrogate splicing-associated mechanisms in hematologic neoplasms.
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Media ReleaseOctober 29, 2024JAX researchers unveil method to map immune cell connections, predicting patient survival in cancer
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study connections between immune cells in breast cancer and melanoma -
ArticleOctober 08, 2024Cancer research trainees advance their skills at JAX with support from the American Cancer Society
Earlier this year, The Jackson Laboratory’s NCI-designated Basic Research Cancer Center and the American Cancer Society (ACS) teamed up to have ACS-funded trainees attend advanced cancer courses at JAX, aiming to deepen their understanding of cutting-edge cancer research techniques through experiential learning. -
Featured ArticleJuly 09, 2024Bringing critical perspectives to genomic medicine research
Leading with compassion, Elizabeth Charnysh represents a team of genetic counselors established seven years ago as part of a comprehensive strategy to study the impact of genomic medicine research on human health. -
Blog PostJune 27, 20245 things: research tools and methods that may be medical game changers
Explore five research tools and methods that didn't exist ten years ago that could be medical game changers.
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Media ReleaseOctober 09, 2024Study probes how eating less can extend lifespan
Researchers at The Jackson Laboratory conduct pivotal study into aging and lifespan to uncover new details about how diets might make people live longer — but also their negative side effects -
Research HighlightJuly 10, 2024Charles Lee continues to sequence repetitive areas of the genome
Charles Lee co-leads the Human Genome Structural Variation Consortium and is uncovering structural variations in the human genome. -
Featured ArticleJuly 09, 2024What is genetic biomarker testing?
Genetic testing is a powerful tool in the fight against cancer, playing a crucial role in both prevention and personalized treatment. But what exactly are the different types of genetic tests, and how do they help? -
Blog PostJune 20, 2024How old is your bone marrow?
Researchers at JAX reveal that hematopoietic stem cells age differently in genetically identical mice, offering new pathways for interventions to preserve health with aging.