Maria Telpoukhovskaia, Ph.D.

Associate Research Scientist

Discovering and targeting microglial pathways involved in cognitive resilience and decline to improve memory during “normal” aging and dementias.

Dementia is an outcome of several neurodegenerative diseases, with no treatments currently available. Microglia, the brain’s immune cells, are implicated in resilience and susceptibility to cognitive decline. The goal of my research is to define the interplay between transcriptomic and functional changes that impact behavior in genetically diverse mouse models of cognitive decline and, subsequently, to discover small molecules that intervene in memory loss.

Education and experience

Education

Gladstone Institute of Neurological Disease
San Francisco, CA, USA
Postdoctoral fellow
Advisor: Dr. Li Gan
2014-2019

University of British Columbia
Vancouver, BC, Canada
Ph.D., Chemistry
Advisor: Dr. Chris Orvig
2009-2014

Yale University
New Haven, CT, USA
B.S., Chemistry
Thesis advisor: Dr. Andrew Hamilton
2003-2007

Experience

University of British Columbia
Vancouver, BC, Canada
Research assistant in Dr. Chris Orvig’s lab
Teaching assistant in analytical chemistry
2009-2014

Angiotech Pharmaceuticals, Inc.
Vancouver, BC, Canada
Research associate 1
2007-2008

Yale University
New Haven, CT, USA
Research assistant in Dr. Andrew Hamilton’s lab
2006-2007

San Francisco State University
San Francisco, CA, USA
Lab volunteer in Dr. Weiming Wu’s lab
2006

University of California, San Francisco
San Francisco, CA, USA
Lab assistant in Dr. Adam Gazzaley’s lab
2006