Gregory Carter, Ph.D.
Professor, The Bernard and Lusia Milch Endowed Chair
Develops computational strategies using genetic data to understand complex genetic systems involving multiple genes and environmental factors.
The Carter Lab uses large-scale data to strengthen the interface between experimental systems and common disease in humans. We develop computational methods to analyze genetic architecture, design translatable studies of model systems, perform data alignment to precisely quantify disease relevance, and share data through open science platforms. Our primary focus is leveraging genetic and genomic data to identify and test potential treatments for Alzheimer’s disease. We are creating and characterizing new mouse and marmoset models to understand the origins and progression of dementia in molecular and pathophysiological detail, and using these models to assess diagnostic biomarkers and perform preclinical testing. Through this work, we are derisking molecular targets to accelerate the discovery of precise, targeted therapeutic approaches. We are embedded in a network of collaborative projects and centers including MODEL-AD, TREAT-AD, and MARMO-AD. By integrating knowledge and standardizing analytical strategies across these research consortia, we are maximizing the translational value of computational and experimental research.
Grants, honors and accomplishments
The IU/JAX/Pitt MODEL-AD Center
Principal Investigator and Head of Bioinformatics and Data Management
NIA U54 AG054345, 2016-2027
Generation, Characterization, and Validation of Marmoset Models of Alzheimer’s Disease (Marmo-AD)
Program Director/Principal Investigator and Head of Bioinformatics and Data Integration
NIA U19 AG074866, 2022-2027
The Open Drug Discovery Center for Alzheimer’s Disease (TREAT-AD)
Principal Investigator and Head of Bioinformatics
NIA U54 AG065187, 2019-2024
Modeling the Genetic Interaction Between Klotho and APOE Alleles in Alzheimer's Disease
Principal Investigator
NIA RF1 AG075701, 2022-2027
An Explainable Unified AI Strategy for Efficient and Robust Integrative Analysis of Multi-omics Data|
Principal Investigator
NIA R21 AG083299, 2023-2025
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP
Co-Investigator
NIA R01 AG060477
Identifying mechanistic pathways underlying RPE pathogenesis in models of pattern dystrophy
Co-Investigator
NEI R01 EY034988
Retinal Disease: Molecular Basis and Pathophysiology Co-Investigator
Co-Investigator
NEI R01 EY011996
Identification of Genetic and Genomic Variants by Next-Gen Sequencing in Nonhuman Animal Models
Co-Investigator
NIDA U01 DA051235, 2021-2026
Full Human Gene Replacement Mouse Models of Alzheimer's Disease
Co-Investigator
NIA RF1 AG079125, 2022-2027
Cancer Center Support
Co-Project Lead
NCI P30 CA034196, 2020-2025
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Featured ArticleOctober 24, 2023Applying AI and machine learning to complex research tasks
JAX researchers are at the forefront of developing and implementing AI-based technologies for a variety of research applications. -
Press ReleaseDecember 19, 2022An outstanding year of growth at The Jackson Laboratory
2022 has been a notable year for The Jackson Laboratory, with great achievements and many reasons to celebrate continued momentum for JAX’s mission. -
ArticleMarch 12, 2021Three new endowed chairs to lead Alzheimer’s, addiction, and cancer research
The Jackson Laboratory (JAX) has appointed three faculty members to endowed chairs in order to further research into Alzheimer’s disease, addiction, cancer and computational biology. -
Research HighlightJune 04, 2020Multiple paths lead to the same destination in Alzheimer's disease
Working with human patient data, a research team led by JAX Associate Professor Greg Carter and summer student Nikhil Milind have identified two distinct subtypes, inflammatory and non-inflammatory, of Alzheimer’s disease. The finding provides important insights for identifying disease biomarkers and therapeutic targets.
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Research HighlightMay 31, 2023Variation in Diversity Outbred mice epigenetics
New research finds that the epigenetic landscape is highly variable between the strains of Diversity Outbred mice and is associated with variation in gene expression. -
Research HighlightMarch 30, 2022JAX is shedding light on new treatments for eye disease
JAX Professor Patsy Nishina and her colleagues have developed mouse models for translational vision research that are now available to the wider biomedical research community. -
Research HighlightSeptember 22, 2020Finding ways to TREAT Alzheimer's disease
The quest to find a cure for Alzheimer’s disease (AD) has almost entirely met with failure at the clinical trial stage. Nonetheless, there have been research advances, particularly during the last few years, that are laying the foundation for progress in the years ahead. -
Research HighlightFebruary 06, 2019JAX collaboration yields important implications for data science
A paper published in Molecular Biology of the Cell leads to important implications for both reproductive biology and data science.