Takeshi Iwasaki, M.D., Ph.D.

Postdoctoral Assocaite

Functional genomics of autoimmune disease associated genetic variants.

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Location

Bar Harbor, ME

Contact

207-288-6000

takeshi.iwasaki@jax.org

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Topics

Bioinformatics
Complex Traits
Computational Biology
Genetics and Genomics
Immune Disorders

As a rheumatologist, I have been exposed to a mysterious clinical course of patients. A person who was fine yesterday develops joint pain, which spreads to systemic arthritis. Behind this, there must be a complex and ever-changing interaction between genetic polymorphisms and the environment. At JAX, I want to disentangle the fundamental rules governing such interactions one by one, since such an accumulation of efforts will lead to the future treatment of each patient.

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Takeshi Iwasaki on Google Scholar

Selected Publications

0 Iwasaki T, Watanabe R, Zhang H, Hashimoto M, Morinobu A, Matsuda F. Identification of the VLDLR locus associated with giant cell arteritis and the possible causal role of low-density lipoprotein cholesterol in its pathogenesis. Rheumatology (Oxford). 2024 Oct 1; 63(10):2754-2762
17 Iwasaki T, Kamatani Y, Sonomura K, Kawaguchi S, Matsuda F. Protocol for genome-wide association study of human blood metabolites. STAR Protoc. 2024 Jun 21; 5(2):103052
64 Fuseya Y, Kadoba K, Liu X, Suetsugu H, Iwasaki T, Ohmura K, Sumida T, Kochi Y, Morinobu A, Terao C, Iwai K. Attenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling. JCI Insight. 2024 Feb 8; 9(3)
39 Iwasaki T, Watanabe R, Ito H, Fujii T, Ohmura K, Yoshitomi H, Murata K, Murakami K, Onishi A, Tanaka M, Matsuda S, Matsuda F, Morinobu A, Hashimoto M. Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis. Arthritis Res Ther. 2024 Jan 2; 26(1):1
0 Nakajima T, Doi H, Watanabe R, Murata K, Takase Y, Inaba R, Itaya T, Iwasaki T, Shirakashi M, Tsuji H, Kitagori K, Akizuki S, Nakashima R, Onishi A, Yoshifuji H, Tanaka M, Ito H, Hashimoto M, Ohmura K, Morinobu A. Factors associated with osteoporosis and fractures in patients with systemic lupus erythematosus: Kyoto Lupus Cohort. Mod Rheumatol. 2023 Dec 22; 34(1):113-121
0 Nakajima S, Tsuchiya H, Ota M, Ogawa M, Yamada S, Yoshida R, Maeda J, Shirai H, Kasai T, Hirose J, Ninagawa K, Fujieda Y, Iwasaki T, Aizaki Y, Kajiyama H, Matsushita M, Kawakami E, Tamura N, Mimura T, Ohmura K, Morinobu A, Atsumi T, Tanaka Y, Takeuchi T, Tanaka S, Okamura T, Fujio K. Synovial Tissue Heterogeneity in Japanese Patients With Rheumatoid Arthritis Elucidated Using a Cell-Type Deconvolution Approach. Arthritis Rheumatol. 2023 Dec; 75(12):2130-2136
0 Onishi A, Tsuji H, Takase Y, Nakakubo Y, Iwasaki T, Kozuki T, Yoshida T, Shirakashi M, Onizawa H, Hiwa R, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Tanaka M, Morinobu A. Comparisons of SLE-DAS and SLEDAI-2K and classification of disease activity based on the SLE-DAS with reference to patient-reported outcomes. Rheumatology (Oxford). 2023 Dec 1; 62(12):3909-3915
0 Yaku A, Ishikawa Y, Iwasaki T, Hiwa R, Matsuo K, Saji H, Yurugi K, Miura Y, Furu M, Ito H, Fujii T, Maekawa T, Hashimoto M, Ohmura K, Mimori T, Terao C. Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF. Rheumatology (Oxford). 2023 May 2; 62(5):2015-2020
32 Gon Y, Kandou T, Tsuruyama T, Iwasaki T, Kitagori K, Murakami K, Nakashima R, Akizuki S, Morinobu A, Hikida M, Mimori T, Yoshifuji H. Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model. PLoS One. 2023; 18(2):e0279389
57 Iwasaki T, Kamatani Y, Sonomura K, Kawaguchi S, Kawaguchi T, Takahashi M, Ohmura K, Sato TA, Matsuda F. Genetic influences on human blood metabolites in the Japanese population. iScience. 2023 Jan 20; 26(1):105738
0 Yamaguchi E, Kadoba K, Watanabe R, Iwasaki T, Kitagori K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Tanaka M, Morinobu A, Yoshifuji H. Clinical profile and outcome of large-vessel giant cell arteritis in Japanese patients: A single-centre retrospective cohort study. Mod Rheumatol. 2023 Jan 3; 33(1):175-181
48 Iwasaki T, Watanabe R, Ito H, Fujii T, Okuma K, Oku T, Hirayama Y, Ohmura K, Murata K, Murakami K, Yoshitomi H, Tanaka M, Matsuda S, Matsuda F, Morinobu A, Hashimoto M. Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis. Front Immunol. 2022; 13:901437

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