Jennifer SanMiguel, Ph.D.

Postdoctoral Associate

Genetic and epigenetic mechanisms of hematopoetic stem cell identity and function, blood cell development, and blood cancers in the context of aging.

Location

Bar Harbor, ME

Contact

207-288-6000

jennifer.sanmiguel@jax.org

Connect

Topics

Aging
Cancer
Genetics and Genomics

Jen joined the Trowbridge lab in August 2018. She is interested in the role of genetics and epigenetics in the blood compartment during normal development, aging, and cancer. Jen received her BA from Colby College. She worked for three years at Children’s Hospital Boston in the laboratory of Dr. Louis Kunkel studying muscular dystrophies before joining Dr. Marisa Bartolomei’s lab at the University of Pennsylvania for her graduate training. Jen’s thesis research focused on the epigenetic regulator, Tet1, and its role in development epigenetic reprogramming, specifically in the context of genomic imprinting.

Selected Publications

116 SanMiguel JM, Bartolomei MS. DNA methylation dynamics of genomic imprinting in mouse development. Biol Reprod. 2018 Jul 1; 99(1):252-262
50 SanMiguel JM, Abramowitz LK, Bartolomei MS. Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring. Development. 2018 Mar 29; 145(7)
64 Ideraabdullah FY, Thorvaldsen JL, Myers JA, Bartolomei MS. Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Hum Mol Genet. 2014 Dec 1; 23(23):6246-59
90 SanMiguel JM, Young K, Trowbridge JJ. Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis. Exp Hematol. 2020 Nov; 91:1-9
38 Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ. Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis. Leukemia. 2019 Jul; 33(7):1635-1649
0 Kawahara G, Gasperini MJ, Myers JA, Widrick JJ, Eran A, Serafini PR, Alexander MS, Pletcher MT, Morris CA, Kunkel LM. Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet. 2015 Aug 1; 24(15):4480-1
107 Alexander MS, Casar JC, Motohashi N, Vieira NM, Eisenberg I, Marshall JL, Gasperini MJ, Lek A, Myers JA, Estrella EA, Kang PB, Shapiro F, Rahimov F, Kawahara G, Widrick JJ, Kunkel LM. MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. J Clin Invest. 2014 Jun; 124(6):2651-67
41 Kawahara G, Gasperini MJ, Myers JA, Widrick JJ, Eran A, Serafini PR, Alexander MS, Pletcher MT, Morris CA, Kunkel LM. Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet. 2014 Apr 1; 23(7):1869-78
67 Motohashi N, Alexander MS, Shimizu-Motohashi Y, Myers JA, Kawahara G, Kunkel LM. Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis. J Cell Sci. 2013 Jun 15; 126(Pt 12):2678-91
40 Gupta VA, Kawahara G, Myers JA, Chen AT, Hall TE, Manzini MC, Currie PD, Zhou Y, Zon LI, Kunkel LM, Beggs AH. A splice site mutation in laminin-α2 results in a severe muscular dystrophy and growth abnormalities in zebrafish. PLoS One. 2012; 7(8):e43794
48 Boyden SE, Mahoney LJ, Kawahara G, Myers JA, Mitsuhashi S, Estrella EA, Duncan AR, Dey F, DeChene ET, Blasko-Goehringer JM, Bönnemann CG, Darras BT, Mendell JR, Lidov HG, Nishino I, Beggs AH, Kunkel LM, Kang PB. Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores. Neurogenetics. 2012 May; 13(2):115-24
69 Cary GA, Cuttler AS, Duda KA, Kusema ET, Myers JA, Tilden AR. Melatonin: neuritogenesis and neuroprotective effects in crustacean x-organ cells. Comp Biochem Physiol A Mol Integr Physiol. 2012 Apr; 161(4):355-60

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