While CD34+ hematopoietic stem cell humanized mice do have a human-like immune system on-board, it is not fully functional. These mice should still be handled very carefully and treated as an immuno-deficient strain. We are glad to offer the following resources to help you care for highly immuno-deficient strains like NSG™. Additionally, you should be sure to check with your institution regarding requirements for housing mice with engrafted human tissue.
Figure 1. CD34 humanized NSG-F15 mice demonstrate stable engraftment of CD45 cells (left) and CD3+ T cells at similar levels as parental strains over 28-weeks. Depicted data is the average of 3 different CD34 donors over 28-week period.
Figure 2. CD34 humanized NSG-F15 mice demonstrate relatively similar abundances of CD33+ myeloid cells as parental CD34 Humanized NSG-FLT3 mice in whole blood (left) and overall higher levels of CD33+ myeloid cells in whole blood as compared to parental strains (right). Depicted data is the average of 3 different CD34 donors over 28-week period.
Figure 3. CD34 humanized NSG-F15 mice demonstrate similar levels of immature NK cells as parental CD34 humanized NSG-FLT3 (top left), similar levels of mature natural killer cells as parental CD34 humanized NSG-IL15 (bottom left and bottom right). Depicted data is the average of 3 different CD34 donors over 28-week period.
Figure 4. CD34 humanized NSG-F15 mice demonstrate lower abundances of CD19+ B cells as compared to CD34 humanized NSG and NSG-FLT3 mice. Depicted data is the average of 3 different CD34 donors over 28-week period.
Figure 5. CD34 humanized NSG-F15 mice demonstrate similar abundances of conventional and plasmacytoid dendritic cells as parental CD34 humanized NSG-FLT3 mice. Depicted data is the average of 3 different CD34 donors over 28-week period.
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