CD34+ Humanized NSG-FLT3-IL15 Mice

Appearance & Care

NSG-FLT3-IL15 Mouse - The Jackson Laboratory

While CD34+ hematopoietic stem cell humanized mice do have a human-like immune system on-board, it is not fully functional. These mice should still be handled very carefully and treated as an immuno-deficient strain. We are glad to offer the following resources to help you care for highly immuno-deficient strains like NSG™. Additionally, you should be sure to check with your institution regarding requirements for housing mice with engrafted human tissue.

Animal Health Reports

AX18 (Maximum)

Phenotype Information

Phenotype Information

hCD45+ Cells
CD34 humanized NSG-FLT3-IL15 - Phenotype Info - CD45 Engraftment
CD3+ T Cells
CD34 Humanized NSG-FLT3-IL15 - Phenotype Info - CD3+ T Cells

Figure 1. CD34 humanized NSG-F15 mice demonstrate stable engraftment of CD45 cells (left) and CD3+ T cells at similar levels as parental strains over 28-weeks. Depicted data is the average of 3 different CD34 donors over 28-week period.

Myeloid Cell Data

CD33+ Myeloid Cells
CD34 Humanized NSG-FLT3-IL15 - Myeloid Cell Data - CD33+ T Cells
CD33+ Myeloid Cells
CD34 Humanized NSG-FLT3-IL15 - Myeloid Cell Data - CD33+ Cells/ul

Figure 2. CD34 humanized NSG-F15 mice demonstrate relatively similar abundances of CD33+ myeloid cells as parental CD34 Humanized NSG-FLT3 mice in whole blood (left) and overall higher levels of CD33+ myeloid cells in whole blood as compared to parental strains (right). Depicted data is the average of 3 different CD34 donors over 28-week period.

Natural Killer Cell Data

Immature Natural Killer Cells
CD34 Humanized NSG-FLT3-IL15 - Immature NK Cell Data

Figure 3. CD34 humanized NSG-F15 mice demonstrate similar levels of immature NK cells as parental CD34 humanized NSG-FLT3 (top left), similar levels of mature natural killer cells as parental CD34 humanized NSG-IL15 (bottom left and bottom right). Depicted data is the average of 3 different CD34 donors over 28-week period.

Mature Natural Killer Cells
CD34 Humanized NSG-FLT3-IL15 - Immature NK Cellular Data
Mature Natural Killer Cells
CD34 Humanized NSG-FLT3-IL15 - NK Cell Data

B Cell Data

CD19+ B Cells
CD34 Humanized NSG-FLT3-IL15 - B Cell Data

Figure 4. CD34 humanized NSG-F15 mice demonstrate lower abundances of CD19+ B cells as compared to CD34 humanized NSG and NSG-FLT3 mice. Depicted data is the average of 3 different CD34 donors over 28-week period.

Dendritic Cells

Conventional Dendritic Cells
CD34 humanized NSG-FLT3-IL15 - Conventional Dendritic Cells
Plasmacytoid Dendritic Cells
CD34 Humanized NSG-FLT3-IL15 - Plasmacytoid Dendritic Cells

Figure 5. CD34 humanized NSG-F15 mice demonstrate similar abundances of conventional and plasmacytoid dendritic cells as parental CD34 humanized NSG-FLT3 mice. Depicted data is the average of 3 different CD34 donors over 28-week period.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

Request a Quote

Instructions

Complete our Humanized Mouse Order Form using the link above (reference stock number 703722)

or

Contact customer service:

orderquest@jax.org
1.800.422.6423 (US)
1.207.288.5845 (International)